Neurohormonal modulation in chronic heart failure
نویسندگان
چکیده
منابع مشابه
Neurohormonal Hypothesis in Heart Failure
A ccording to the neurohormonal model, heart failure is a syndrome that develops because an initial heart injury activates endogenous neurohormonal systems that exert a deleterious effect to the myocardium and on the circulation. This new model regards heart failure primarily as a neurohormonal disorder with main pathophysiologic abnormality the activation of various neurohormonal systems. Arte...
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Decompensation in heart failure occurs when the heart fails to balance venous return with cardiac output, leading to fluid congestion and contributing to mortality. Decompensated heart failure can cause acute kidney injury (AKI), which further increases mortality. Heart failure activates signaling systems that are deleterious to kidneys such as renal sympathetic nerve activity (RSNA), renin-ang...
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Clinical Use of Digitalis Glycosides The potential benefit of digoxin therapy in heart failure patients is thought to be related to its positive inotropic effect that increases cardiac output and thereby decreases ventricular filling pressures.2 Although digoxin is undoubtedly an inotropic agent in tissue preparations,3 this effect, in contrast to other inotropic agents, is not consistently tra...
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BACKGROUND Neurohormonal activation characterizes chronic heart failure, relates to outcome, and is a therapeutic target. It is not known whether a similar pattern of neurohormonal activation exists in adults with congenital heart disease and, if so, whether it relates to common measures of disease severity or whether cardiac anatomy is a better discriminant. METHODS AND RESULTS Concentration...
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Copyright © Polskie Towarzystwo Kardiologiczne INTRODUCTION The most recent version of the European Society of Cardiology (ESC) Guidelines for the management of heart failure (HF) has introduced two important innovations for the medical treatment of chronic HF with reduced ejection fraction (EF): mineralo-corticoid receptor antagonists (MCRA) and the If channel blocker ivabradine have now a rec...
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ژورنال
عنوان ژورنال: European Heart Journal Supplements
سال: 2002
ISSN: 1520-765X
DOI: 10.1016/s1520-765x(02)90154-9